Vitamin B12 and the Brain

Speaker: H. Refsum Presented at: 2015 The New York Academy of Sciences


Typical vitamin B12 deficiency is characterized by megaloblastic anemia combined with neuropsychiatric symptoms. This talk focus on the limitations of meta-analysis that argued B vitamins have no beneficial effect on development of dementia and or cognitive decline. The presentation will focus on data from the Vitacog trial and other studies to argue the case that B vitamins, in particular B12, slow brain atrophy and delay cognitive decline in the subgroup of the population that is likely to benefit.