HMO Academy

Human Milk Oligosaccharides (HMOs) are complex sugars that are available in human milk. They are the 3rd largest solid component in breast milk after fat and lactose and have no nutritive function. HMOs are responsible for directly stimulating the immune system by promoting good gut bacteria, strengthening the gut barrier function and blocking pathogens.

Human Milk Oligosaccharides are an exciting and central area of research in infant nutrition. Scientific advances on HMOs are helping us know more about the role and importance of these essential components of Human milk. The HMO Academy has been created to share evidence-based information in interactive and user-friendly way from more than a decade of research on HMOs.

Library >

Acute respiratory infections in breastfed infants
Article

Acute Respiratory Infections in breastfed infants: Role of maternal secretor status and nasopharyngeal microbiome

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The Nest

The Nest 40: Human Milk Oligosaccharides

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Abstract Brochure

Human Milk Oligosaccharides support immune protection

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Abstract Brochure

Nestlé Research on Human Milk Oligosaccharides: Latest Update

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Article

HMOs: New Ways to Shape the Gut Microbiome in CMPA

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The Nest

The Nest 44: Pro-, Pre-, and Synbiotics: Myths and Facts

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Abstract Brochure

From Basic Science to Clinical Implication: The HMO Story So Far

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Abstract Brochure

Human Milk Oligosaccharides: Where Do We Go from Here?

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NNIW Brochure

NNIW88 Brochure: Intestinal Microbiome: Functional Aspects in Health & Disease

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NNIW Brochure

NNIW90 Brochure: Human Milk: Composition, Clinical Benefits and Future Opportunities

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Article

First clinical study to report on the effects of supplementation with 2 HMOs

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Article

Human Milk Oligosaccharides: the Link between Mother’s and Baby’s Health

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Article

2’fucosyllactose is well tolerated in a partially hydrolyzed Whey Protein

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Article

Benefits of two Human Milk Oligosaccharides, 2FL and LNnT in Infant Nutrition

Videos >

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Video Teaser

Yvan Vandenplas: How HMOs Boost Immunity

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Video

Viktor Bauer: Term infant formula supplemented with a unique blend of 5 HMOs

Florence Rochat: Impact of HMO on toddler microbiota and its activity
Video

Florence Rochat: Impact of HMO on toddler microbiota and its activity

Lars Bode: The Science of HMO's what they are and what they do
Video Teaser

Lars Bode: The Science of HMO's what they are and what they do

Sagar Thakkar: Lactation for infant feeding expertise (LIFE) focus on HMO's
Video Teaser

Sagar Thakkar: Lactation for infant feeding expertise (LIFE) focus on HMO's

Ryan Carvalho: Learnings from the last decade of clinical evidence on HMOs
Video Teaser

Ryan Carvalho: Learnings from the last decade of clinical evidence on HMOs

Philippe Alliet: Term Infant Formula Supplemented with 2’FL Reduces the Abundance of Pathogenic Bacteria during Early Infancy
Video

Philippe Alliet: Term Infant Formula Supplemented with 2’FL Reduces the Abundance of Pathogenic Bacteria during Early Infancy

HMO diversity impacts infant microbiota activity
Video

Florence Rochat: HMO diversity impacts infant microbiota activity

Aristea Binea: HMO levels in breast milk do not correlate or predict infant growth
Video

Aristea Binea: HMO levels in breast milk do not correlate or predict infant growth

Carine Blanchard: HMOs and allergic sensitization: current evidence
Video Teaser

Carine Blanchard: HMOs and allergic sensitization: current evidence

Jane Natividad: Human Milk Oligosaccharides Confer Resistance against Inflammation-mediated Intestinal Epithelial Barrier Dysfunction
Video

Jane Natividad: Human Milk Oligosaccharides Confer Resistance against Inflammation-mediated Intestinal Epithelial Barrier Dysfunction

Jane Natividad: Microbial Products Derived From HMO Fermentation by Infant Microbiota Protect Against Inflammation
Video

Jane Natividad: Microbial Products Derived From HMO Fermentation by Infant Microbiota Protect Against Inflammation

Jonas Hauser: Early Life Presence of 6’SL Alters Microbiota
Video

Jonas Hauser: Early Life Presence of 6’SL Alters Microbiota

Jonas Hauser: Sialylated HMOs are Shaping the Development of Cognitive Functions
Video

Jonas Hauser: Sialylated HMOs are Shaping the Development of Cognitive Functions

Jonas Hauser: Early Life Supplementation with Blends of (HMO) Improves Cognitive Functions
Video

Jonas Hauser: Early Life Supplementation with Blends of (HMO) Improves Cognitive Functions

Weili Lin: A Positive Correlation between Breast Milk 3’ Sialyllactose and Language Development
Video

Weili Lin: A Positive Correlation between Breast Milk 3’ Sialyllactose and Language Development

Jonas Hauser: Glutamatergic Gene Expression Mediates the Relationship between Gut Bacteria
Video

Jonas Hauser: Glutamatergic Gene Expression Mediates the Relationship between Gut Bacteria

Sharon Donovan: Human Milk Oligosaccharides and Neonatal Immunity
Video Teaser

Sharon Donovan: Human Milk Oligosaccharides and Neonatal Immunity

Hania Szajewska: Evidence-based Medicine and HMOs
Video Teaser

Hania Szajewska: Evidence-based Medicine and HMOs

Norbert Sprenger: Human milk oligosaccharides factors
Expert Interview

Norbert Sprenger: Human milk oligosaccharides factors

Lars Bode: Human Milk Oligosaccharides: next Generation Functions and Questions
Video Teaser

Lars Bode: Human Milk Oligosaccharides: next Generation Functions and Questions

Philippe Alliet: Clinical Studies: what is known and what needs further Studies?
Video Teaser

Philippe Alliet: Clinical Studies: what is known and what needs further Studies?

Yvan Vandenplas: HMOs story so far
Video Teaser

Yvan Vandenplas: HMOs story so far

Seppo Salminen: Human Milk Oligosaccharides: regulatory Aspects
Video Teaser

Seppo Salminen: Human Milk Oligosaccharides: regulatory Aspects

Lars Bode: Milk Oligosaccharides structure and function
Expert Interview

Lars Bode: Milk Oligosaccharides structure and function

Clemens Kunz: HMOs: just a Sugar or Nature’s secret Weapon
Video Teaser

Clemens Kunz: HMOs: just a Sugar or Nature’s secret Weapon

Norbert Sprenger: HMO – physiological Significance
Video Teaser

Norbert Sprenger: HMO – physiological Significance

Functional insights in HMOs
Video teaser

Functional Insights in HMOs, Key early Life Bioactives

Continuous Medical Education >

Module 1: Human Milk Oligosaccharides: Basic Science and Physiological Significance
Tutorial

Module 1: Human Milk Oligosaccharides: Basic Science and Physiological Significance

Module 2: Effects of Human Milk Oligosaccharides on Gut Microbiota and beyond
Tutorial

Module 2: Effects of Human Milk Oligosaccharides on Gut Microbiota and beyond

Module 3: Role of Human Milk Oligosaccharides in the Protection against Infections and Necrotising Enterocolitis
Tutorial

Module 3: Role of Human Milk Oligosaccharides in the Protection against Infections and Necrotising Enterocolitis

Module 4: Human Milk Oligosaccharides: Complex structure and Specific Functional Benefits
Tutorial

Module 4: Human Milk Oligosaccharides: Complex structure and Specific Functional Benefits

Module 5 Human Milk Oligosaccharides: Clinical Evidence
Tutorial

Module 5 Human Milk Oligosaccharides: Clinical Evidence

New findings on HMO research
Tutorial

New findings on HMO research

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Practical Resources >

role of HMOs slide deck preview
Presentation Slides

Role of HMOs in Preterm Nutrition

Human Milk Oligosaccharides: A Child's Health Guardian
Infographic

Human Milk Oligosaccharides: A Child's Health Guardian

Human Milk Oligosaccharides: Help Strengthen an Infant's Immunity
Infographic

Human Milk Oligosaccharides: Help Strengthen an Infant's Immunity

how can preterm infants benefit from human milk oligosaccharides landscape.png
Infographic

How Can Preterm Infants Benefit From Human Milk Oligosaccharides

What are HMOs: basic science
Presentation Slides

What are HMOs: basic science

the benefits of HMOs on immunity.png
Infographic

The benefits of Human Milk Oligosaccharides on immunity

Human Milk Oligosaccharides (structure and functions)
Infographic

Human Milk Oligosaccharides (structure and functions)

2’fucosyllactose is well tolerated in a partially hydrolysed Whey Protein Infant Formula with a probiotic
Publication Digest

2’fucosyllactose is well tolerated in a partially hydrolysed Whey Protein Infant Formula with a probiotic

HMOs: clinical studies
Presentation Slides

HMOs: clinical studies

Effects of Infant Formula with HMOs on Growth and Morbidity
Publication Digest

Effects of Infant Formula with HMOs on Growth and Morbidity

Infants fed a Formula containing 2’FL have lower inflammatory Cytokines
Publication Digest

Infants fed a Formula containing 2’FL have lower inflammatory Cytokines

How do HMOs support babies immunity
Fast Facts

How do HMOs support babies immunity

Addition of 2’FL brings Infant Formulae closer to Human Milk
Publication Digest

Addition of 2’FL brings Infant Formulae closer to Human Milk

Innate Protection conferred by fucosylated Oligosaccharides
Publication Digest

Innate Protection conferred by fucosylated Oligosaccharides

What makes HMOs unique?
Fast Facts

What makes HMOs unique?

Do HMOs have a protective role in reducing the risk of respitory infections
Fast Facts

Do HMOs have a protective role in reducing the risk of respitory infections

News >

Content of HMO 2FL in breast milk is associated with higher cognitive development scores at 2 years
News

Content of HMO 2FL in breast milk is associated with higher cognitive development scores at 2 years

Human Milk Oligosaccharides may play a role in Childhood Obesity Prevention?
News

Human Milk Oligosaccharides may play a role in Childhood Obesity Prevention?

HMOs in Infant Formula – Latest Research Reviewed
News

HMOs in Infant Formula – Latest Research Reviewed

Immunological Effects of Human Milk Oligosaccharides: New Scientific Review
News

Immunological Effects of Human Milk Oligosaccharides: New Scientific Review

HMO, 6’Sialyllactose in early Life plays a key Role in the Brain Development of Mice
News

HMO, 6’Sialyllactose in early Life plays a key Role in the Brain Development of Mice

Role of 2′-fucosylated HMOs in the Reduction of respiratory Infections in Babies
News

Role of 2′-fucosylated HMOs in the Reduction of respiratory Infections in Babies

HMOs stimulate Bifidobacteria that contribute to reduce the Risk of lower Respiratory Tract Illnesses
News

HMOs stimulate Bifidobacteria that contribute to reduce the Risk of lower Respiratory Tract Illnesses

HMOs, 6’SL, in pre-weaning Milk modulates Microbiota Composition and improves adult Cognitive Functions
News

HMOs, 6’SL, in pre-weaning Milk modulates Microbiota Composition and improves adult Cognitive Functions

HMOs, 3′SL, in pre-weaning Milk influences Attention, Learning and Memory later in Life
News

HMOs, 3′SL, in pre-weaning Milk influences Attention, Learning and Memory later in Life

Related Resources >

Frequently Asked Questions

Frequently Asked Questions