The Nest 40: Human Milk Oligosaccharides

Editor(s): C. Kunz, N. Sprenger, S.M. Donovan. / 40

This issue of The Nest discusses an important topic of Human Milk Oligosaccharides (HMO) and its role in infant nutrition and short and long-term health benefits. First Clemens Kunz explains the background and history of human milkoligosaccharides and its metabolism. Norbert Sprenger follows this topic by focusing on the impact of HMO on the mucosal immune protection through the microbiota and mucosalimmune system. In her manuscript, Sharon Donovan describes HMO as diverse,biologically active components that beneficially modulate the infant microbiotaas well as the gut, immune, and potentially neurological development.


Human Milk Oligosaccharides and the Infant Gut Microbiome

Author(s): S.M. Donovan

Human milk oligosaccharides (HMOs) are diverse, biologically active components that benefi cially modulate the infant microbiota as well as gut, immune, and potentially neurological development. It is now possible to produce large quantities of HMOs enabling supplementation to infant formula, with the goal of supporting the gut microbiota composition and developmental outcomes more similar to that of the breastfed infant.