Generation Next of HMOs: the breakthrough research
Topic(s): Allergy Gut Microbiota
Human milk oligosaccharides (HMOs) are an abundant group of diverse bioactives that can be generally categorized accordingly to theirs structures into: Non-fucosylated (core), fucosylated, sialylateds. Current evidence suggests that the structure of an HMO determines its function; in other words, not all HMOs do the same. Various studies have shown that specific HMOs impact immune, gut and brain health. Mechanisms behind some of these benefits include the impact on microbiome, epithelial barrier functions and immune & cellular pathways. New avenues of potential future benefits now seen in pre-clinical models are the impact of early life HMOs exposure on later bone health and influence on allergic outcomes.