Long-term effects of hydrolyzed formulae on atopic diseases in the GINI study

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Prevention of allergic disease in children has been on the agenda for many decades. Although several studies have been performed in the last 3 decades with both types of hydrolyzed formulae (extensively and partially hydrolyzed) with regard to their ability to prevent allergic diseases, the most important findings derive from the German Infant Nutritional Intervention study (GINI). The GINI study is by far the largest study in the field of allergy prevention with hydrolysates and the study with the longest follow-up (up to now until 20 years). The findings confirm the concept that early nutritional intervention with certain hydrolyzed formulae, if exclusive breastfeeding is not feasible, has a preventive effect until adulthood for both eczema and allergic airway manifestation.