NNIW28 - Long Chain Fatty Acids

Editor(s): U. Bracco, R.J. Deckelbaum. vol. 28


Fatty Acids in Human Biology: Past and Future

Author(s): A.A. Spector

This review is a brief summary of the nutritional, metabolic, and functional roles of fatty acids in mammalian Systems, with emphasis on processes that play a role in human physiology and diseases. In this context I will point out existing gaps in our knowledge about fatty acids and suggest areas that appear to be most promising for further study.

Long Chain Fatty Acid Metabolism

Author(s): H. Sprecher

In recent years it has become ever more apparent that a variety of physiological processes are in part mediated by the types of unsaturated acids esterified in membranelipids.

Physical Properties of Fatty Acids and Their Extracellular and Intracellular Distribution

Author(s): D.M. Small

Fatty acids are ubiquitous biological molecules. They are esterifïed to many com-plex lipids such as triacylglycerols, phospholipids, and cholesterol esters, and as part of those molecules determine some of their physical properties.

Long Chain Fatty Acids and Other Lipid Second Messengers

Author(s): A.H. Merrill

The ability of long chain fatty acids and complex lipids to control cell behavior was once thought to reside solely in their function as sources of energy and as structural elements for cells and tissues.

Long Chain Fatty Acids: Intake, Digestion, and Absorption in Newborn Infants

Author(s): O. Hernell, L. Blàckberg

Triglyceride (triacylglycerol) constitutes more than 98% of the dietary fat and provides about half the energy intake for breast-fed as well as formula-fed infants. Each triglyceride molecule consists of three fatty acids esterified to one molecule of glycerol.

Long Chain Fatty Acids and Peroxisomal Disorders

Author(s): H.W. Moser, A.B. Moser

A connection between peroxisomes and fatty acid metabolism was established first by Lazarow and deDuve in 1976, who demonstrated a fatty acid coenzyme A (CoA) oxidizing System in rat liver that is enhanced by peroxisome proliferators (1).

Long Chain Polyunsaturated Fatty Acid Metabolism and Cellular Utilization: Regulation and Interactions

Author(s): C. Galli, C. Mosconi, F. Marangoni

The unique presence of the long chain highly unsaturated fatty acids (HUFA) of the linoleic (LA) and the a linolenic (LNA) acid series in the animal kingdom under-lines the existence of specialized mechanisms for the incorporation and maintenance of these compounds, which are present in biological Systems mainly as esters of glycerol in phospholipids, as structural components of biomembranes.

Essential Fatty Acids in Early Development

Author(s): M.A. Crawford, K. Costeloe, W. Doyle, A. Leaf, M. J. Leighfîeld, N. Meadows, A. Phylactos

From Swedish and British data, the incidence of cerebral palsy in low birthweightand premature infants has risen nearly threefold since the mid 1960s.

Developmental Aspects of Long Chain Polyunsaturated Fatty Acid Metabolism: Cns Development

Author(s): M.T. Clandinin, J.E.E. Van Aerde

Brain development is a sequential process characterized by stages of growth and maturation (1). Biochemical transitions in brain development are also sequential, paralleling anatomical changes (2).

Supply, Uptake, and Utilization of Docosahexaenoic Acid During Photoreceptor Cell Differentiation

Author(s): N.G. Bazan

During the perinatal development of brain and retina profound changes in cell structure, organization, and function occur.

Long Chain Polyunsaturated Fatty Acids in the Diets of Premature Infants

Author(s): B. Koletzko

In the past, guidelines on the feeding of premature infants have recommended adietary supply of linoleic and partly also of a linolenic acid but not of any otheressential fatty acids (1-3).

Dietary Long Chain Polyunsaturated Fatty Acids: Sources, Problems, and Uses

Author(s): U. Bracco

Infant formulas generally derive their lipid composition from vegetable and animal oils and thus do not contain polyunsaturated fatty acids with chain lengths more than 18 carbon atoms.

Long Chain Fatty Acid Metabolism and Essential Fatty Acid Deficiency With Special Emphasis on Cystic Fibrosis

Author(s): B. Strandvik

Cystic fibrosis (CF) is a recessive hereditary disease which for many years has been the most common serious disease of childhood in Caucasians (1).

Effects of Dietary Essential Fatty Acid Balance on Behavior and Chronic Diseases

Author(s): H. Okuyama

Beneficiai effects of supplementing fish oil hâve been studied extensively (1,2),and eicosapentaenoic acid (20: 5n-3, EPA) ethylester was recently developed in Japanas a treatment for thrombotic disease.

Long Chain Fatty Acids in Obstetrics, Gynecology and Fertility: A Focus on Non-Eicosanoid-Mediated Mechanisms

Author(s): J.Y. Jeremy

It has long been recognized that certain fatty acids (for example, linoleic and arachidonic) are essential for ail aspects of mammalian reproductive function, at least in the laboratory animal (1-4).

Thymus Eicosanoids are Involved in Tolerance to Self

Author(s): N. Gualde

The thymus is the major site for generating mature thymocytes with a broad repertoireof ? cell receptors for the recognition of foreign epitopes (1).

Long Chain Fatty Acids and Atopic Dermatitis

Author(s): L. Juhlin

Atopic dermatitis (atopic eczema) is a common skin disorder which typically begins in the 3rd to 6th month of life and affects at least 3% of infants.

Long Chain Fatty Acids and Cholesterol Metabolism

Author(s): R.J. Deckelbaum

Early in the 20th century it was recognized that diet could affect atherosclerosis. Anitschkow and Chalatow reported atherosclerosis in rabbits who were fed diets rich in cholesterol (1).