Infantile colic, otherwise known as excessive crying, is one of the most common reasons for parents to consult their pediatricians, especially during the first few months of their infants’ life. Apart from causing considerable stress to parents, management of colic also presents as a significant challenge for the caregivers. Although the exact cause of infantile colic is unknown, various factors may act in tandem, leading to gastrointestinal tract disturbances that result in excessive, inconsolable crying in infants. The composition of gut microbiota is strongly associated with infantile colic, and altering the gut microbiota may be one of the potential ways to resolve colic in infants. Probiotics, such as Lactobacillus reuteri, has shown to be effective in treating infantile colic because of their ability to alter the gut microbiota.