News article

Probiotics can reduce bowel problem in premature babies

Posted:  Thursday, December 19, 2013

A 3-strain probiotic blend can reduce the occurrence of a bowel condition common among premature babies, researchers writing in Pediatrics journal have found. The researchers, drawn from a variety of research institutions and universities, said the blend reduced the bowel complication, necrotizing enterocolitis (NEC), but showed no clear effect on late-onset sepsis, a blood infection that typically affects premature infants younger than 90 days old.

The multicenter, double-blinded, placebo-controlled, randomised trial compared daily use of Bifidobacterium infantis, Streptococcus thermophilus, and Bifidobacterium lactis with placebo among infants born before 32 weeks and weighing less than 1.5kg.

The study analysed 1099 babies selected between October 2007 and November 2011 in Australia and New Zealand.

“The probiotics B infantis, S thermophilus, and B lactis significantly reduced NEC of Bell stage 2 or more in very preterm infants, but not definite late-onset sepsis or mortality. Treatment with this combination of probiotics appears to be safe,” the researchers concluded.

Christian Barker, executive VP in the Health & Nutrition Division at Chr Hansen, the Danish supplier of the probiotics in question, welcomed the study.

“We have a strong focus on infant health and support research initiatives that will enable us to make continuous advancements. The study findings are remarkable. From a commercial point of view, however, NEC is a small area compared to other indications such as functional bowel disorders and diarrhea."


Pediatrics Vol. 132 No. 6, December 1, 2013, pp. 1055 -1062 (doi: 10.1542/peds.2013-1339) ‘Probiotic Effects on Late-onset Sepsis in Very Preterm Infants: A Randomized Controlled Trial’ Authors: Susan E. Jacobs, MD et al…

For study details:-Click Here!