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Oxidative stress in renal artery blamed for CVD in kids with small kidneys

Posted:  Thursday, February 05, 2015

Oxidative stress in the renal artery could predispose infants born with small kidneys to chronic kidney disease, high blood pressure and cardiovascular disease (CVD) as adults, found a new study.

Published in the journal Circulation, the study conducted by researchers from Monash University and University of Queensland evaluated the effect of reduced renal mass on the mechanisms that regulate kidney and blood vessel function.

They found that in case of infants with smaller kidneys, there was an increased response to nerve activity and an inability to respond to nitric oxide, an important determinant of blood vessel health. Both these events promote kidney injury.

Approximately 1 in 500 babies are affected with renal disorders at birth. Many go on to lead normal lives whereas some are plagued by chronic kidney disease (CKD) and high blood pressure. These conditions precipitate end stage kidney disease and consequently the need for dialysis in children.

Talking about CKD, the researchers said, “New imaging technologies are making it easier to identify affected babies. However, early detection and intervention significantly improves outcomes. So, we need to understand much more about the mechanisms that drive kidney injury.”

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