EAACI 2020

Food Allergy and Anaphylaxis Meeting and the European Consortium on Application of Flow Cytometry in Allergy (FAAM-EUROBAT) Digital 2020

Human Milk Oligosaccharides: New Developments in the Management of Cow’s Milk Protein Allergy

Human milk oligosaccharides (HMO) are the third largest component in breastmilk. They resemble mucosal glycans at the host–microbe interface, supporting HMO to play important roles in orchestrating the host–microbial interactions via multiple mechanisms. These include preventing pathogen growth and adhesion, reducing inflammatory responses and aiding the mucosal barrier function, as well as promoting an early life microbiome. Observational studies with breastfed infants suggest that HMO  support the immune system with protection from infections and possibly allergies. It has been shown that feeding a formula with the two HMO, 2’FL and LNnT, reduces the risk for infections in both healthy and infants with cow’s milk protein allergy. Furthermore, feeding a formula with these two HMO supports a gut microbiota closer to breastfed infants. In this symposium we will learn more about the effect of HMO supplementation on the gut microbiome in children with cow’s milk protein allergy

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