Obesity Treatment and Prevention: New Directions' to the topic

Editor(s): A. Drewnowski, B. Rolls NNI Workshop Series (NNIW) Vol.73 , 2012


Obesity remains a large public health issue. Therefore, the NNI dedicated a workshop entitled:  'Obesity Treatment and Prevention: New Directions' to the topic. Prof. A. Drewnowski and Prof. B. Rolls established an outstanding scientific program which is published in the PubMed indexed Nestlé Nutrition Institute Workshop book series.

  • Brain Reorganization following Weight Loss

    Author(s): M. Rosenbaum

    The long- term stability of bodyweight despite wide variation in energy intake and expenditure suggests that at usual weight energy intake and output are ‘coupled’ to maintain body energy stores. Our model for some of the molecular mechanics of this regulation of energy stores is based on the concept of a neurally encoded ‘threshold’ for minimum body fat, below which compensatory physiology is invoked to restore body fat. The existence of such a centrally encoded threshold is supported by the similarities in response to maintenance of a reduced weight between lean and obese individuals, and the tendency for weight- reduced individuals to regain weight to levels of fat stores similar to those present prior to initial weight loss. Brain responses to food and the observed changes in energy expenditure that occur during maintenance of a reduced weight are largely reversed by the administration of the adipocyte- derived hormone, leptin.

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