Thalassaemia syndromes result from reduced or
absent production of one or more globin chains
of the human haemoglobins .
Sickle cell disease is an inherited condition that is
common among, but not confined to, peoples of
Haemoglobin E (HbE) is the most common abnormal
haemoglobin in South East Asia, especially
among the Austroasiatic ethnic group such as
Khmer, Laos, Mon/Khmer speaking peoples and
among the Zhuang in Guangxi, Peoples Republic
of China [1-4].
The major haemoglobinopathies include the thalassaemias,
haemoglobin E disorders and sickle
Haemoglobinopathies refer to a group of hereditary disorders that affect genes responsible for synthesis
of the protein moity of haemoglobins. These disorders lead to an imbalance in or defective globin synthesis,
shorter red cell life-span, and generally chronic anaemia.