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GINI Study Reveals Results of Allergic Manifestation 15 Years After Early Intervention with Hydrolyzed Formulas

Posted:  Monday, February 22, 2016

Fifteen years ago, the German Infant Nutritional Intervention (GINI) study set out to assess the association between early intervention with hydrolyzed formulas in children with a high–risk of developing allergies and the actual allergic outcomes in infancy.

With data on the long-term impact of hydrolyzed formulas on allergies being scarce, the long-duration of this study was an important factor. GINI trial participants received one of four formulas in the first four months of life as breastmilk substitute if necessary: partial or extensive whey hydrolyzate (pHF-W, eHF-W), extensive casein hydrolyzate (eHF-C) or standard cow´s milk formula (CMF) as reference. Associations between these formulas and the cumulative incidence and prevalence of parent reported physician-diagnosed Asthma, allergic rhinitis (AR) and eczema, as well as spirometric indices and sensitization, were examined using generalized linear models.

The results of the 15-year follow-up of the GINI study confirm that the previously reported preventative effect of the eHF-C and pHF-W formulas on eczema are sustained until adolescence without the existence of a rebound phenomenon. Most importantly it also shows that during the last years of follow-up there was significant effect of eHF-C and pHF-W related to fewer emergences of hay fever/allergic rhinitis. There was also lower prevalence of asthma in the eHF-C and pHF-W groups, but not significant in the latter. None of the formulas had an influence on IgE sensitization. 

This is the first long term study of hydrolysates testing the effect of eHF-C and pHF-W on allergy outcomes at 15 years of age. The most striking and consistent effect for both the eHF-C and pHF-W is the reduced development of eczema from birth onwards. However the significant effect in reduction of allergic rhinitis is also relevant. 

The findings with respect to the respiratory allergies should be interpreted with caution until confirmed in future studies

Read the full article: Allergic manifestation 15 years after early intervention with Hydrolyzed formulas – the GINI Study

GINI study results at 10 years