The world now sees an alarming situation of increased and perpetually rising incidence of obesity as well as diabetes. The statistics point to a grave scenario as the occurrence of obesity in adolescents has tripled and in general population has doubled in the past 30 years. A systematic review was undertaken to assess the impact of interventions that can prevent and manage obesity, pre-diabetes and diabetes in women and adolescent. In this talk Prof Lassi shows there is evidence to support exercise as an intervention to decrease the risk of gestational diabetes mellitus (GDM), preeclampsia, maternal weight gain, and increase the chance of a normal delivery. Physical activity is not only effective in reducing weight in women, but the evidence was more convincing as it reduces the risk of GDM by 53%.