Preterm infants’ hospital discharge is often delayed due totheir inability to feed by mouth safely and competently. Noevidence-based supported guidelines are currently availablefor health-care professionals caring for these infants.Available interventions advocating benefits are not readilyacknowledged for lack of rigorous documentation inasmuchas any improvements may ensue from infants’ normal maturation. Through research, a growing understanding of thedevelopment of nutritive sucking skills has emerged, sheddinglight on how and why infants may encounter oral feedingdifficulties due to the immaturity of specific physiologicfunctions. Unfortunately, this knowledge has yet to be translatedto the clinical practice to improve the diagnoses of oralfeeding problems through the development of relevant assessmenttools and to enhance infants’ oral feeding skillsthrough the development of efficacious preventive andtherapeutic interventions. This review focuses on the maturationof the various physiologic functions implicated in thetransport of a bolus from the oral cavity to the stomach. Althoughinfants’ readiness for oral feeding is deemed attainedwhen suck, swallow, and respiration are coordinated,we do not have a clear definition of what coordination implies.We have learned that each of these functions encompassesa number of elements that mature at different timesand rates. Consequently, it would appear that the properfunctioning of sucking, the swallow processing, and respirationneed to occur at two levels: first, the elements withineach function must reach an appropriate functional maturationthat can work in synchrony with each other to generatean appropriate suck, swallow process, and respiration; andsecond, the elements of all these distinct functions, in turn,must be able to do the same at an integrative level to ensurethe safe and efficient transport of a bolus from the mouth tothe stomach.